ʻO ka Pharmacodynamics flufenicol kahi lāʻau lapaʻau ākea ākea.
ʻO nā aminools, kahi bacteriosuppressor, a hana ma ka hoʻopaʻa ʻana me ka ribosome 50s subunit e kāohi i ka synthesis o nā protein bacterial. Loaʻa iā ia ka hana antibacterial ikaika e kūʻē i nā ʻano bacteria gram-positive a me gram-negative. ʻO Pasteurella hemolyticus, pasteurella multocida a me actinobacillus suis pleuropneumoniae ua paʻakikī loa i ka flufenicol. I loko o ka vitro, ua like a ʻoi aku ka ikaika o ka hana antimicrobial o ka flufenicol e kūʻē i nā microorganism he nui ma mua o ka sulfenicol, a ʻo kekahi mau bacteria i kū i ka aminools ma muli o ka acetylation, e like me ka escherichia coli a me ka klebsiella pneumoniae, hiki ke maʻalahi i ka flufenicol.
Hoʻohana nui ʻia ia no nā maʻi bacterial o ka puaʻa, ka moa a me ka iʻa i hana ʻia e nā maʻi maʻi maʻi, e like me nā maʻi hanu o nā pipi a me nā puaʻa i hoʻokumu ʻia e pasteurella hemolyticus, pasteurella multocida a me actinobacillus pleuropneumoniae. ʻO ka typhoid a me ka paratyphoid i hoʻokumuʻia e ka salmonella, ka moa kolera, ka moa keʻokeʻo keʻokeʻo, colibacillosis, etc.; iʻa pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis a me nā maʻi bacteria ʻē aʻe i hana ʻia e ka iʻa bacterial septicemia, enteritis, erythroderma a me ka koke.
Hoʻopili koke ʻia ka pharmacokinetics flufenicol e ka hoʻokele kūloko, a hiki ke loaʻa ka ʻike therapeutic i loko o ke koko ma hope o 1 hola, a hiki ke loaʻa ke kiʻekiʻe o ke koko ma 1 a 3 mau hola. ʻOi aku ka bioavailability ma mua o 80%. Hoʻolaha nui ʻia ʻo Flufenicol i nā holoholona a hiki ke hele i ka pale koko-lolo. Hoʻokuʻu ʻia ʻo ia i loko o ka mimi i kona ʻano kumu a ma nā wahi liʻiliʻi i loko o nā faeces.
1. Loaʻa i nā Macrolides a me nā lincoamine ka pahuhopu like me kēia huahana, ua hui pū ʻia lākou me ka ribosome bacterial 50s subunit, a hiki ke hana i nā hopena antagonistic ke hui pū ʻia.
2. Hiki ke kū'ē i ka hana bactericidal o nā penicillins a i ʻole aminoglycosides, akā ʻaʻole i hōʻoia ʻia i nā holoholona.
ʻO nā lāʻau lapaʻau Amidoalcohol, pili loa iā Pasteurella hemolyticus, Pasteurella multocida a me actinobacillus pleuropneumoniae, i hoʻohana ʻia no nā maʻi Pasteurella a me Escherichia coli.
Intramuscular injection: hoʻokahi pānaʻi, no 1kg ke kaumaha o ke kino, 0.2ml no ka moa, 0.15 ~ 0.2ml no nā hipa a me nā puaʻa, 0.075 ~ 0.1ml no nā lio a me nā pipi. Hoʻokahi manawa i kēlā me kēia 48 hola, ʻelua mau manawa. ʻO ka iʻa 0.005 a 0.01ml hoʻokahi manawa i ka lā.
1. Loaʻa i kēia huahana kekahi hopena immunosuppressive ke hoʻohana ʻia i ʻoi aku ka nui ma mua o ka nui i ʻōlelo ʻia.
2. Loaʻa iā ia ka ʻawaʻawa fetal, a pono e hoʻohana ʻia me ka akahele i ka wā hāpai a me ka lactating holoholona.
1. kapu ka hoomoe ana o na moa.
2. ʻAʻole pono e pāpā ʻia nā holoholona me ke kino kīnā ʻole a i ʻole ka wā o ka lāʻau lapaʻau.
3. Pono e hoemi pono na holoholona me ka lawa ole o ka renal.
