No nā lāʻau lapaʻau aminoglycoside ka Pharmacodynamic damamycin, a loaʻa ka hopena inhibitory maʻamau i nā ʻano bacilli gram-negative, e like me escherichia coli, salmonella, shigella, proteus a pēlā aku. He mea maʻalahi ia i ka streptococcus, pneumococcus, staphylococcus epidermidis a me kekahi mycoplasma (e like me mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, etc.). ʻAʻole maʻalahi ia i ka streptococcus viridis a me staphylococcus aureus. He mea maʻamau ka pale ʻana i ka pseudomonas aeruginosa a me treponemas. Kū'ē nui ka bacteria intestinal i ka megamycin, akā ʻaʻole hōʻike i ke kūʻē kea me streptomycin. Loaʻa i ka Lincomycin ka hana antibacterial maikaʻi e kūʻē i ka maʻi bacteria anaerobic, e like me clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens a me ka hapa nui o nā actinomyces. Hana nui ʻo Lincomycin i ka subunit 50s o nā ribosomes bacteria, e hoʻopilikia i ka synthesis protein ma ke kāohi ʻana i ka hoʻonui ʻana o ke kaulahao peptide.
ʻO ka Pharmacokinetics he 7% wale nō o ka lincomycin i hoʻopaʻa ʻia ma hope o ka hoʻokele kūloko, akā mālama ia i kahi kiʻekiʻe kiʻekiʻe ma ka gastrointestinal tract. ʻOi aku ka haʻahaʻa o ke kino o ka lāʻau ma mua o ka serum. ʻAʻole maʻalahi ke komo i ka wai cerebrospinal a i ʻole ka maka, a ʻaʻole kiʻekiʻe ka paʻa o ka protein plasma. Hoʻokuʻu ʻia ka hapa nui o nā lāʻau e ka kānana glomerular i ko lākou ʻano kumu. ʻO ka bioavailability o lincomycin he 30% ~ 40% me ka maikaʻi ʻole o ka absorption i ka hoʻokele waha. Hiki ke ho'emi 'ia ka helu absorption a me ka nui o ka lincomycin ma o ka hanai hui 'ana. Hāʻawi ʻia nā moa i 50mg o kēia huahana (hoʻoheheʻe ʻia i ka wai inu) no ka kg o ke kaumaha o ke kino no 7 mau lā. I ka wā o ka hoʻāʻo ʻana, ua hōʻea ka lincomycin plasma i ka 0.14 μg / ml, ʻoiai he liʻiliʻi loa ka neʻe ʻana o ka daguanmycin. Ma hope o 7 mau lā o ka hoʻāʻo, ua ʻoi aku ma mua o 0.1μg/ml.
1. Hoʻohuiʻia me ka lincomycin, hiki ke hoʻonui nui i ka hana antibacterial e kū'ē i ka mycoplasma a hoʻonui i ka spectrum antibacterial.
2. ʻO ka hui pū ʻana o ka lincomycin a me nā lāʻau anticholinesterase hiki ke hōʻemi i ka hopena o ka hopena.
3. Hoʻohui pū ʻia me ka erythromycin ka hopena antagonistic.
Nā lāʻau lapaʻau. No ka ma'i bacteria Gram-negative, bacteria Gram-positive a me ka ma'i mycoplasma.
Mea inu: 100g o kēia huahana i hui ʻia me ka wai 200 ~ 300kg no ka puaʻa a me 50 ~ 100kg no ka moa no 3 ~ 5 mau lā. ʻO ka hānai hui ʻia: 100g hānai hui ʻia 100kg no nā puaʻa a me 50kg no nā moa, hoʻohana ʻia no 5 a 7 mau lā.
E lūlū i ka mālama olakino: Mai 7 mau lā ma mua o ka hoʻopuka ʻana a i 7 mau lā ma hope o ka hoʻopuka ʻana, 100g o kēia huahana i hui pū ʻia me 100kg, a i ʻole 200kg me ka wai. Ka mālama ola kino puaʻa: Ma mua a ma hope o ka wean a me ka pae hānai, 100g hui 100kg, a i ʻole 200kg wai.
ʻAʻole i ʻike ʻia nā hopena ʻino i ka wā i hoʻohana ʻia e like me ka hoʻohana ʻana a me ka dosage.
